The small molecules we screen come from multiple sources both external and internal, including small libraries and individual compounds synthesized in our lab. In addition, during the process of making molecules to support our chemical biology studies, particularly work on new small-molecule probes of cell migration and related studies, we have also explored new synthetic methodology.
More on chemical modulators of cell migration, including:
Eddy, N.A.; Richardson, J.J.; Fenteany, G.
The effect of Lewis acids on the cycloaddition of
3,3,6-trimethylcyclohex-5-ene-1,2,4-trione: hydrogen transfer
versus cycloaddition with cyclopentadiene. Eur. J. Org.
Chem. 2013, 2013 (23),
Eddy, N.A.; Kelly, C.B.; Mercadante, M.A.; Leadbeater, N.E.; Fenteany, G. Access to dienophilic ene-triketone synthons by oxidation of diketones with an oxoammonium salt. Org. Lett. 2012, 14, 498�501. [Abstract] [HTML] [PDF]
Beshir, A.B.; Guchhait, S.K.; Gasc�n, J.A.; Fenteany, G. Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. Bioorg. Med. Chem. Lett. 2008, 8, 498-504. [Abstract] [HTML] [PDF]
Ankala, S.V.; Fenteany, G. Aryl, alkyl bis-silyl ethers: rapid access to monoprotected aryl alkyl and biaryl ethers. Synlett 2003, 6, 825-828.[PDF]